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Published by New Science Press, this text introduces general principles of protein structure, folding, and function, then goes beyond these basics to tackle the conceptual basis of inferring structure and function from genomic sequence. It is the first book in a series, Primers in Biology, employing a modular design in which chapters are divided into topics, each occupying one two-page spread that includes the relevant text, illustrations (in full color), definitions, and references.
The book has five chapters. The first is an introduction to the principles of protein structure and folding, with emphasis on proteins' biophysical properties. The second describes the principles of the main biochemical functions of proteins, namely binding and catalysis, with a short section on the properties of structural proteins. Chapter 3 covers the regulation of protein function, containing concise descriptions of all the regulatory mechanisms that operate on proteins, from pH to phosphorylation, with several sections on protein switches based on nucleotide hydrolysis. Chapter 4 introduces the principles whereby structure and function are deduced from sequence, with illustrative examples. The final chapter addresses how data on protein structure is gathered, interpreted, and presented.
Written for upper-level undergraduates and beginning graduate students, Protein Structure and Function will also be useful for working scientists needing an up-to-date introduction to the field.
- Sales Rank: #231762 in Books
- Brand: Petsko, Gregory A./ Ringe, Dagmar
- Published on: 2003-08-01
- Original language: English
- Number of items: 1
- Dimensions: 10.75" h x 8.25" w x .50" l, 1.70 pounds
- Binding: Paperback
- 180 pages
- Used Book in Good Condition
Review
"This reviewer has not encountered a book better than this one for students interested in learning more about structure-function relationships in proteins." --B. Williams, Choice
"The modular structure works well for this primer. ... The authors stress the concepts underlying protein structure, regulation, design, and mechanism. These are the fundamentals that students often miss in the rush to memorize details. ... For teachers, the organization of the book makes it easy to arrange a course or series of lectures by simply picking and choosing the topics to be covered. For students, this volume provides a well-organized introduction to protein structure and function with up-to-date references to the literature." --Steven Smith, The Quarterly Review of Biology
"The modular structure works well for this primer. ... The authors stress the concepts underlying protein structure, regulation, design, and mechanism. These are the fundamentals that students often miss in the rush to memorize details. ... For teachers, the organization of the book makes it easy to arrange a course or series of lectures by simply picking and choosing the topics to be covered. For students, this volume provides a well-organized introduction to protein structure and function with up-to-date references to the literature." --Steven Smith, The Quarterly Review of Biology
About the Author
Gregory A Petsko studied chemistry and classics as an undergraduate at Princeton University before going to Oxford as a Rhodes scholar to work for his PhD with David Phillips. He then pursued his interest in the mechanism of enzyme catalysis at the Massachusetts Institute of Technology where he taught courses in chemistry and detective fiction, before moving to Brandeis where he is currently Director of the Rosenstiel Center and has extended his research interests to include the use of yeast genetics to study the unfolded protein response pathway, and the mechanism of action of the ABC transporter proteins. Dagmar Ringe graduated in chemistry from Barnard College, Columbia, and took her PhD in bioorganic chemistry from Boston University. She then pursued her research interest in the study of enzyme catalysis by X-ray crystallography at the Massachusetts Institute of Technology before moving to Brandeis where she is Professor of Biochemistry and Chemistry and where the principal focus of her research is on structure-function relationships in enzymes of particular industrial and pharmaceutical importance.
Most helpful customer reviews
6 of 6 people found the following review helpful.
To the point introduction
By Emmanouela Filippidi
It is great! Concise, to the point, with good illustrations, teaches you the essentials of protein structure and function in little time.
2 of 2 people found the following review helpful.
Quality and content of the book.
By Joshua M. Muia
Generally,the book is excellent and the information is condensed in a simple language which can be understood easily. I also liked the proteins cartoons, the protein data bank number,fantastic! In additions, the book have links,words or terms defination and further references which proves to be helpful.
0 of 0 people found the following review helpful.
Less dry than usual, good reference
By JTC
This is a good reference that is written in a less dry style than most textbooks, which appears to happen once you get to graduate level textbooks. It is a good book for biochemists and those who use biochemistry; I read this book to develop an understanding of my techniques involving antibodies and target proteins.
I recommend skimming through a copy before you buy, to determine if you will benefit from it (it may be too specialized for some, and some chemistry background is very helpful).
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