Kamis, 19 Mei 2011

[F687.Ebook] Download Ebook Alex Zanardi: My Story, by Alex Zanardi, Gianluca Gasparini

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Alex Zanardi: My Story, by Alex Zanardi, Gianluca Gasparini

As sporting heroes go, you don't get much bolder than ex-Champ car ace Alex Zanardi. When he lost both legs in a terrible accident in 2001, Zanardi was determined to compete again. Two years later, at his first comeback race, a European Touring Car Championship round at Monza, he finished just 15 seconds behind the winner. Here is his inspirational story, written by Zanardi with Gianluca Gasparini - it has received remarkable reviews and become a best-seller.

  • Sales Rank: #466683 in Books
  • Brand: Brand: J H Haynes Co Ltd
  • Published on: 2004-09-28
  • Ingredients: Example Ingredients
  • Original language: English
  • Number of items: 1
  • Dimensions: .0" h x .0" w x .0" l, 1.10 pounds
  • Binding: Hardcover
  • 376 pages
Features
  • Used Book in Good Condition

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0 of 0 people found the following review helpful.
Remarkable story
By William Riddell
Former Indy Car champion and Formula 1 driver Alex Zanardi shares his incredible life story.

From his humble but adventure filled childhood through to the horrific crash that claimed his legs (& nearly his life) and his inspiration comeback against all odds.

This emotional roller coaster makes you feel so happy to be alive and so inspired by Zanardi's magnificent tale.

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Selasa, 17 Mei 2011

[E627.Ebook] Download I Believe in the Holy Spirit: v. 2, by Cardinal Yves Congar

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I Believe in the Holy Spirit is a major treatise on the topic by one of the great theologians of the century. Yves Congar's book is one of the few comprehensive treatments of the Church's understanding of the Spirit and the working of the Spirit in the life of the Church by a Roman Catholic theologian.

  • Sales Rank: #4050018 in Books
  • Published on: 1983-07
  • Original language: French
  • Number of items: 1
  • Binding: Hardcover
  • 240 pages

Language Notes
Text: English, French (translation)

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Kamis, 12 Mei 2011

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This book addresses one of the most critical issues facing global business leaders and the multicultural workforce – how to work and relate effectively in the intercultural contexts. The author presents business professionals, practitioners and academics with the Collaborative Intercultural Competence Model. Based on solid theoretical assumptions and real intercultural experiences, this model is to help professionals work more effectively across and within cultures. This book expands the traditional presentation of existing knowledge by providing a unified discussion of intercultural communication and its conceptual foundations. The book offers readers with a contemporary insight into the intercultural competence phenomenon and highlights the basis for its experience-based inquiry, assessment and development.

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Rabu, 04 Mei 2011

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THE #1 NEW YORK TIMES BESTSELLER

From the Pulitzer Prize-winning, bestselling author of The Emperor of All Maladies—a magnificent history of the gene and a response to the defining question of the future: What becomes of being human when we learn to “read” and “write” our own genetic information?

Siddhartha Mukherjee has a written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

Throughout the narrative, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—cuts like a bright, red line, reminding us of the many questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In superb prose and with an instinct for the dramatic scene, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.

As The New Yorker said of The Emperor of All Maladies, “It’s hard to think of many books for a general audience that have rendered any area of modern science and technology with such intelligence, accessibility, and compassion…An extraordinary achievement.” Riveting, revelatory, and magisterial history of a scientific idea coming to life, and an essential preparation for the moral complexity introduced by our ability to create or “write” the human genome, The Gene is a must-read for everyone concerned about the definition and future of humanity. This is the most crucial science of our time, intimately explained by a master.

  • Sales Rank: #702 in Books
  • Published on: 2016-05-17
  • Released on: 2016-05-17
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.25" h x 1.70" w x 6.12" l, .0 pounds
  • Binding: Hardcover
  • 608 pages

Amazon.com Review
An Amazon Best Book of May 2016: In 2010, Siddhartha Mukherjee was awarded the Pulitzer Prize for his book The Emperor of All Maladies, a “biography” of cancer. Here, he follows up with a biography of the gene—and The Gene is just as informative, wise, and well-written as that first book. Mukherjee opens with a survey of how the gene first came to be conceptualized and understood, taking us through the thoughts of Aristotle, Darwin, Mendel, Thomas Morgan, and others; he finishes the section with a look at the case of Carrie Buck (to whom the book is dedicated), who eventually was sterilized in 1927 in a famous American eugenics case. Carrie Buck’s sterilization comes as a warning that informs the rest of the book. This is what can happen when we start tinkering with this most personal science and misunderstand the ethical implications of those tinkerings. Through the rest of The Gene, Mukherjee clearly and skillfully illustrates how the science has grown so much more advanced and complicated since the 1920s—we are developing the capacity to directly manipulate the human genome—and how the ethical questions have also grown much more complicated. We could ask for no wiser, more fascinating and talented writer to guide us into the future of our human heredity than Siddhartha Mukherjee. --Chris Schluep

Review
"This is perhaps the greatest detective story ever told—a millennia-long search, led by a thousand explorers, from Aristotle to Mendel to Francis Collins, for the question marks at the center of every living cell. Like The Emperor of All Maladies, The Gene is prodigious, sweeping, and ultimately transcendent. If you’re interested in what it means to be human, today and in the tomorrows to come, you must read this book." (Anthony Doerr, author of All the Light We Cannot See)

"The Gene is a magnificent synthesis of the science of life, and forces all to confront the essence of that science as well as the ethical and philosophical challenges to our conception of what constitutes being human." (Paul Berg, winner of the Nobel Prize in Chemistry)

"Compelling... Highly recommended." (Booklist, starred review)

“Sobering, humbling, and extraordinarily rich reading from a wise and gifted writer who sees how far we have come—but how much farther far we have to go to understand our human nature and destiny.” (Kirkus, starred review)

"Mukherjee deftly relates the basic scientific facts about the way genes are believed to function, while making clear the aspects of genetics that remain unknown. He offers insight into both the scientific process and the sociology of science... By relating familial information, Mukherjee grounds the abstract in the personal to add power and poignancy to his excellent narrative." (Publishers Weekly, starred review)

“A magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick. . . . [The Gene] will confirm [Mukherjee] as our era’s preeminent popular historian of medicine. The Gene boats an even more ambitious sweep of human endeavor than its predecessor. . . . Mukherjee punctuates his encyclopedic investigations of collective and individual heritability, and our closing in on the genetic technologies that will transform how we will shape our own genome, with evocative personal anecdotes, deft literary allusions, wonderfully apt metaphors, and an irrepressible intellectual brio.” (Ben Dickinson, Elle)

“Magnificent…. The story [of the gene] has been told, piecemeal, in different ways, but never before with the scope and grandeur that Siddhartha Mukherjee brings to his new history… he views his subject panoptically, from a great and clarifying height, yet also intimately.” (James Gleick, New York Times Book Review)

“Many of the same qualities that made The Emperor of All Maladies so pleasurable are in full bloom in The Gene. The book is compassionate, tautly synthesized, packed with unfamiliar details about familiar people.” (Jennifer Senior, The New York Times)

“Mukherjee’s visceral and thought-provoking descriptions... clearly show what he is capable of, both as a writer and as a thinker.” (Matthew Cobb, Nature)

“His topic is compelling. . . . And it couldn’t have come at a better time.” (Courtney Humphries, Boston Globe)

"[Mukherjee] nourishes his dry topics into engaging reading, expresses abstract intellectual ideas through emotional stories . . . .[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry. . . . . With a marriage of architectural precision and luscious narrative, an eye for both the paradoxical detail and the unsettling irony, and a genius for locating the emotional truths buried in chemical abstractions, Mukherjee leaves you feeling as though you've just aced a college course for which you'd been afraid to register -- and enjoyed every minute of it." (Andrew Solomon, Washington Post)

“The Gene is equally authoritative [to Emperor], building on extensive research and erudition, and examining the Gordian knots of genes through the prism of his own family’s struggle with a disease. He renders complex science with a novelist’s skill for conjuring real lives, seismic events.” (Hamilton Cain, Minneapolis Star Tribune)

“A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future. . . . The Gene captures the scientific method—questioning, researching, hypothesizing, experimenting, analyzing—in all its messy, fumbling glory, corkscrewing its way to deeper understanding and new questions.” (Jim Higgins, Milwaukee Journal-Sentinel)

“This is an intimate history. . . . This is a meticulous history. . . . This is a provocative history. . . . Most of all, this is a readable history. . . . The Gene is a story that, once read, makes us far better educated to think about the profound questions that will confront us in the coming decades.” (Ron Krall, Steamboat Today)

“Reading The Gene is like taking a course from a brilliant and passionate professor who is just sure he can make you understand what he’s talking about. . . . The Gene is excellent preparation for all the quandaries to come.” (Mary Ann Gwinn, Seattle Times)

“Inspiring and tremendously evocative reading. . . . Like its predecessor, [The Gene] is both expansive and accessible . . . . In The Gene, Mukherjee spends most of his time looking into the past, and what he finds is consistently intriguing. But his sober warning about the future might be the book’s most important contribution.” (Kevin Canfield, San Francisco Chronicle)

“Destined to soar into the firmament of the year’s must reads, to win accolades and well-deserved prizes, and to set a new standard for lyrical science writing. . . . Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost. . . . Thanks to Dr. Mukherjee’s remarkably clear and compelling prose, the reader has a fighting chance of arriving at the story of today’s genetic manipulations with an actual understanding of both the immensely complicated science and the even more complicated moral questions.”  (Abigail Zuger, New York Times Science Section)

“[The Emperor of All Maladies and The Gene] both beautifully navigate a sea of complicated medical information in a way that is digestible, poignant, and engaging . . . . [The Gene] is a book we all should read. I shook my head countless times while devouring it, wondering how the author—a brilliant physician, scientist, writer, and Rhodes Scholar—could possibly possess so many unique talents. When I closed the book for the final time, I had the answer: Must be in the genes.” (Matt McCarthy, USA Today)

“A brilliant exploration of some of our age’s most important social issues, from poverty to mental illness to the death penalty, and a beautiful, profound meditation on the truly human forces that drive them. It is disturbing, insightful, and mesmerizing in equal measure.”  (Coastal Current)

“Dr Mukherjee uses personal experience to particularly good effect. . . . Perhaps the most powerful lesson of Dr Mukherjee’s book [is]: genetics is starting to reveal how much the human race has to gain from tinkering with its genome, but still has precious little to say about how much we might lose.”  (The Economist)

“As compelling and revealing as [The Emperor of All Maladies]. . . . On one level, The Gene is a comprehensive compendium of well-told stories with a human touch. But at a deeper level, the book is far more than a simple science history.” (Fred Bortz, Dalls Morning News)

“Mukherjee is an assured, polished wordsmith . . . who displays a penchant for the odd adroit aphorism and well-placed pun. . . . A well-written, accessible, and entertaining account of one of the most important of all scientific revolutions, one that is destined to have a fundamental impact on the lives of generations to come. The Gene is an important guide to that future.” (Robin McKie, The Guardian)

About the Author
Siddhartha Mukherjee is the author of The Emperor of All Maladies: A Biography of Cancer, winner of the 2011 Pulitzer Prize in general nonfiction, and The Laws of Medicine. He is the editor of Best Science Writing 2013. Mukherjee is an assistant professor of medicine at Columbia University and a cancer physician and researcher. A Rhodes scholar, he graduated from Stanford University, University of Oxford, and Harvard Medical School. He has published articles in Nature, The New England Journal of Medicine, The New York Times, and Cell. He lives in New York with his wife and daughters. Visit his website at: SiddharthaMukherjee.com

 

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188 of 201 people found the following review helpful.
"We used to think our future was in the stars. Now we know it's in our genes."
By Ash Jogalekar
Genetics is humanity and life writ large, and this book on the gene by physician and writer Siddhartha Mukherjee paints on a canvas as large as life itself. It deals with both the history of genetics and its applications in health and disease. It shows us that studying the gene not only holds the potential to transform the treatment of human disease and to feed the world’s burgeoning population, but promises to provide a window into life’s deepest secrets and into our very identity as human beings.

The volume benefits from Mukherjee’s elegant literary style, novelist’s eye for character sketches and expansive feel for human history. While there is ample explanation of the science, the focus is really on the brilliant human beings who made it all possible. The author’s own troubling family history of mental illness serves as a backdrop and keeps on rearing its head like a looming, unresolved question. The story begins with a trip to an asylum to see his troubled cousin; two of his uncles have also suffered from various "unravelings of the mind". This burden of personal inheritance sets the stage for many of the questions about nature, nurture and destiny asked in the pages that follow.

The book can roughly be divided into two parts. The first part is a sweeping and vivid history of genetics. The second half is a meditation on what studying the gene means for human biology and medicine.

The account is more or less chronological and this approach naturally serves the historical portion well. Mukherjee does a commendable job shedding light on the signal historical achievements of the men and women who deciphered the secret of life. Kicking off from the Greeks’ nebulous but intriguing ideas on heredity, the book settles on the genetics pioneer Gregor Mendel. Mendel was an abbot in a little known town in Central Europe whose pioneering experiments on pea plants provided the first window into the gene and evolution. He discovered that discrete traits could be transmitted in statistically predictable ways from one generation to next. Darwin came tantalizingly close to discovering Mendel’s ideas (the two were contemporaries), but inheritance was one of the few things he got wrong. Instead, a triumvirate of scientists rediscovered Mendel’s work almost thirty years after his death and spread the word far and wide. Mendel’s work shows us that genius can emerge from the most unlikely quarters; one wonders how rapidly his work might have been disseminated had the Internet been around.

The baton of the gene was next picked up by Francis Galton, Darwin’s cousin. Galton was the father of eugenics. Eugenics has now acquired a bad reputation, but Galton was a polymath who made important contributions to science by introducing statistics and measurements in the study of genetic differences. Many of the early eugenicists subscribed to the racial theories that were common in those days; many of them were well intended if patronizing, seeking to ‘improve the weak’, but they did not see the ominous slippery slope which they were on. Sadly their ideas fed into the unfortunate history of eugenics in America and Europe. Eugenics was enthusiastically supported in the United States; Mukherjee discusses the infamous Supreme Court case in which Oliver Wendell Holmes sanctioned the forced sterilization of an unfortunate woman named Carrie Buck by proclaiming, “Three generations of imbeciles are enough”. Another misuse of genetics was by Trofim Lysenko who tried to use Lamarck’s theories of acquired characteristics in doomed agricultural campaigns in Stalinist Russia; as an absurd example, he tried to “re educate” wheat using “shock therapy”. The horrific racial depredations of the Nazis which the narrative documents in some detail of course “put the ultimate mark of shame” on eugenics.

The book then moves on to Thomas Hunt Morgan’s very important experiments on fruit flies. Morgan and his colleagues found a potent tool to study gene propagation in naturally occurring mutations. Mutations in specific genes (for instance ones causing changes in eye color) allowed them to track the flow of genetic material through several generations. Not only did they make the crucial discovery that genes lie on chromosomes, but they also discovered that genes could be inherited (and also segregated) in groups rather than by themselves. Mukherjee also has an eye for historical detail; for example, right at the time that Morgan was experimenting on flies, Russia was experimenting with a bloody revolution. This coincidence gives Mukherjee an opening to discuss hemophilia in the Russian royal family – a genetically inherited disease. A parallel discussion talks about the fusion of Darwin's and Mendel’s ideas by Ronald Fisher, Theodosius Dobzhansky and others into a modern theory of genetics supported by statistical reasoning in the 40s – what’s called the Modern Synthesis.

Morgan and others’ work paved the way to recognizing that the gene is not just some abstract, ether-like ghost which transmits itself into the next generation but a material entity. That material entity was called DNA. The scientists most important for recognizing this fact were Frederick Griffiths and Oswald Avery and Mukherjee tells their story well; however I would have appreciated a fuller account of Friedrich Miescher who discovered DNA in pus bandages from soldiers. Griffiths showed that DNA can be responsible for converting non-virulent bacteria to virulent ones; Avery showed that it is a distinct molecule separate from protein (a lot of people believed that proteins with their functional significance were the hereditary material).

All these events set the stage for the golden age of molecular biology, the deciphering of the structure of DNA by James Watson (to whom the quote in the title is attributed), Francis Crick, Rosalind Franklin and others. Many of these pioneers were inspired by a little book by physicist Erwin Schrodinger which argued that the gene could be understood using precise principles of physics and chemistry; his arguments turned biology into a reductionist science. Mukherjee’s account of this seminal discovery is crisp and vivid. He documents Franklin’s struggles and unfair treatment as well as Watson and Crick’s do-what-it-takes attitude to use all possible information to crack the DNA puzzle. As a woman in a man’s establishment Franklin was in turn patronized and sidelined, but unlike Watson and Crick she was averse to building models and applying the principles of chemistry to the problem, two traits that were key to the duo’s success.

The structure of DNA of course inaugurated one of the most sparkling periods in the history of intellectual thought since it immediately suggested an exact mechanism for copying the hereditary material as well as a link between DNA and proteins which are the workhorses of life. The major thread following from DNA to protein was the cracking of the genetic code which specifies a correspondence between nucleotides on a gene and the amino acids of a protein: the guiding philosophers in this effort were Francis Crick and Sydney Brenner. A parallel thread follows the crucial work of the French biologists Francois Jacob and Jacques Monod - both of whom had fought in the French resistance during World War 2 - in establishing the mechanism of gene regulation. All these developments laid the foundation for our modern era of genetic engineering.

The book devotes a great deal of space to this foundation and does so with verve and authority. It talks about early efforts to sequence the gene at Harvard and Cambridge and describes the founding of Genentech, the first company to exploit the new technology which pioneered many uses of genes for producing drugs and hormones: much of this important work was done with phages, viruses which infect bacteria. There is also an important foray into using genetics to understand embryology and human development, a topic with ponderous implications for our future. With the new technology also came new moral issues, as exemplified by the 1975 Asilomar conference which tried to hammer out agreements for the responsible use of genetic engineering. I am glad Mukherjee emphasizes these events, since their importance is only going to grow as genetic technology becomes more widespread and accessible.

These early efforts exploded on to the stage when the Human Genome Project (HGP) was announced, and that’s where the first part of the book roughly ends. Beginning with the HGP, the second part mainly focuses on the medical history and implications of the gene. Mukherjee’s discussion of the HGP focuses mainly on the rivalries between the scientists and the competing efforts led by Francis Collins of the NIH and Craig Venter, the maverick scientist who broke off and started his own company. This discussion is somewhat brief but it culminates in the announcement of the map of the human genome at the White House in 2000. It is clear now that this “map” was no more than a listing of components; we still have to understand what the components mean. Part of that lake of ignorance was revealed by the discovery of so-called ‘epigenetic’ elements that modify not the basic sequence of DNA but the way it’s expressed. Epigenetics is an as yet ill-understood mix of gene and environment which the book describes in some detail. It’s worth noting that Mukherjee’s discussion of epigenetics has faced some criticism lately, especially based on his article on the topic in the New Yorker.

The book then talks about early successes in correlating genes with illness that came with the advent of the human genome and epigenome; genetics has been very useful in finding determinants and drugs for diseases like sickle cell anemia, childhood leukemia, breast cancer and cystic fibrosis. Mukherjee especially has an excellent account of Nancy Wexler, the discoverer of the gene causing Huntington’s disease, whose search for its origins led her to families stricken with the malady in remote parts of Venezuela. While such diseases have clear genetic determinants, as Mukherjee expounds upon at length, genetic causes for diseases like cancer, diabetes and especially the mental illness which plagues members of the author’s family are woefully ill-understood, largely because they are multifactorial and suffer from weakly correlated markers. We have a long way to go before the majority of human diseases can be treated using gene-based treatment. In its latter half the book also describes attempts to link genes to homosexuality, race, IQ, temperament and gender identity. The basic verdict is that while there is undoubtedly a genetic component to all these factors, the complex interplay between genes and environment means that it’s very difficult currently to tease apart influences from the two. More research is clearly needed.

The last part of the book focuses on some cutting edge research on genetics that’s uncovering both potent tools for precise gene engineering as well as deep insights into human evolution. A notable section of the book is devoted to the recent discovery that Neanderthals and humans most likely interbred. Transgenic organisms, stem cells and gene therapy also get a healthy review, and the author talks about successes and failures in these areas (an account of a gene therapy trial gone wrong is poignant and rattling) as well as ethical and political questions which they raise. Finally, a new technology called CRISPR which has taken the world of science by storm gets an honorary mention: by promising to edit and propagate genes with unprecedented precision - even in the germ line - CRISPR has resurrected all the angels and demons from the history of genetics. What we decide about technologies like CRISPR today will impact what our children do tomorrow. The clock is ticking.

In a project as ambitious as this there are bound to be a few gaps. Some of the gaps left me a bit befuddled though. There are a few minor scientific infelicities: for instance Linus Pauling’s structure of DNA was not really flawed because of a lack of magnesium ions but mainly because it sported a form of the phosphate groups that wouldn’t exist at the marginally alkaline pH of the human body. The book’s treatment of the genetic code leaves out some key exciting moments, such as when a scientific bombshell from biochemist Marshall Nirenberg disrupted a major meeting in the former Soviet Union. I also kept wondering how any discussion of DNA’s history could omit the famous Meselson-Stahl experiment; this experiment which very elegantly illuminated the central feature of DNA replication has been called “the most beautiful experiment in biology”. Similarly I could see no mention of Barbara McClintock whose experiments on ‘jumping genes’ were critical in understanding how genes can be turned on and off. I was also surprised to find few details on a technique called PCR without which modern genetic research would be virtually impossible: both PCR and its inventor Kary Mullis have a colorful history that would have been worth including. Similarly, details of cutting-edge sequencing techniques which have outpaced Moore’s Law are also largely omitted. I understand that a 600 page history cannot include every single scientific detail, but some of these omissions seem to me to be too important to be left out.

More broadly, there is no discussion of the pros and cons of using DNA to convict criminals: that would have made for a compelling human interest story. Nor is there much exploration of using gene sequences to illuminate the ‘tree of life’ which Darwin tantalizingly pulled the veil back on: in general I would have appreciated a bigger discussion of how DNA connects us to all living creatures. There are likewise no accounts of some of the fascinating applications of DNA in archaeological investigations. Finally, and this is not his fault, the author suffers from the natural disadvantage of not being able to interview many of the pioneers of molecular biology since they aren’t around any more (fortunately, Horace Freeland Judson’s superb “The Eighth Day of Creation” fills this gap: Judson got to interview almost every one of them for his book). This makes his account of science sound a bit more linear than the messy, human process that it is.

The volume ends by contemplating some philosophical questions: What are the moral and societal implications of being able to engineer genomes even in the fetal stage? How do we control the evils to which genetic technology can be put? What is natural and what isn’t in the age of the artificial gene? How do we balance the relentless, almost inevitable pace of science with the human quest for responsible conduct, dignity and equality? Mukherjee leaves us with a picture of these questions as well as one of his family and their shared burden of mental illness: a mirage searching for realization, a sea of questions looking for a tiny boat filled with answers.

Overall I found “The Gene: An Intimate History” to be beautifully written with a literary flair, and in spite of the omissions, the parts of genetic history and medicine which it does discuss are important and instructive. Its human stories are poignant, its lessons for the future pregnant with pitfalls and possibilities. Its sweeping profile of life’s innermost secrets could not help but remind me of a Japanese proverb quoted by physicist Richard Feynman: “To every man is given the key to the gates of heaven. The same key opens the gates of hell.” The gene is the ultimate key of this kind, and Mukherjee’s book explores its fine contours in all their glory and tragedy. We have a choice in deciding which of these contours we want to follow.

28 of 28 people found the following review helpful.
The author's biggest success is in weaving a beautiful narrative. Starting with the emotionally-charged personal links to ...
By NJ
Gene is a must-read history book on genetics. Many accounts have been penned on Relativity and Quantum Mechanics, for instance, to make their importance known to the non-professionals. Gene fills the void for the equally important science of Genetics.

The author's biggest success is in weaving a beautiful narrative. Starting with the emotionally-charged personal links to the field to the frequent detailing of personalities of or anecdotes involving famous scientists, the subject is kept 'human'. There are abundant scientific notions to satisfy any reader picking up the book to understand the real subject matter, but not in the general bland fashion of studies-and-conclusions that tend to lose many a lay people.

The book also excels because of the simplicity with which countless exotic concepts are explained. From the notions of introns and exons to the polygenic nature of most phenotypes, the feedback from environment to gene mutation and the massive role played by non-gene factors in most our traits, the author uncovers a staggering number of interesting findings in a highly understandable manner.

Amid all this, the author keeps the focus on various moral and ethical issues. The narrative is laced with historic episodes of all kinds to emphasise the criticality of the questions confronting us as we make more scientific progress. For example, the book beautifully explains the dangers of genetic modification - which tantamounts to replacing natural selection with human selection. As professionals or parents seek to weed out certain deformities, there are genuine risks of us eliminating some important evolutionary traits mainly out of ignorance of how genes really work at this stage but also out of their possible other utilities in long future.

The biggest flaw of the book is insufficient focus on latest developments and near absence of what this science is capable of solving in coming decades. The optimists out there expect congenitally blind people to see and cancers all cured. Some expect us to be able to grow a third arm if we so choose or re-create a dinosaur in a century or so. Genetics is combined with nanotechnology, cryonics, robotics etc by many fantasizers to come up with even more fanciful theories. The author could have added a chapter or two to discuss gene therapy and other recent experiments to complete the excellent work further.

That said, a remarkable book in all aspects.

3 of 3 people found the following review helpful.
A six star book
By Brian Hunt
Dr. Mukherjee’s earlier book, The Emperor of All Maladies, a book on cancer, is on my list of all-time top ten books. His new book is also at or close to the same level: It is a six star book on a scale of one to five. Dr. Mukherjee writes beautifully and with extraordinary clarity on very difficult technical subjects, moving effortlessly from complex, detailed biochemical processes to enormous ethical issues affecting our very future as a species.

This book is a masterful story of the history of genetics, starting from Mendel and Darwin right up to the latest gene modification processes; it is the clearest and most comprehensive account that I have read. But it is much more because Dr. Mukherjee introduces us to human dramas involving both researchers and patients. He also sets out the moral issues of our growing power to change the genomes not only of living people and embryos but also of descendants who have yet to be conceived.

Woven through the book is the personal story of Dr. Mukherjee’s family, which has a history of schizophrenia. Two of Dr. Mukherjee’s uncles and one of his first cousins suffered the devastating effects of schizophrenia and he lives with the possibility that he, too, may someday be struck down and/or have passed the disruptive genes on to his children.

This is not a lightweight book but I found it easy to read, thanks to the elegance of the writing, and totally gripping. As Dr. Mukherjee makes clear, we stand on the brink of a genetic future that has great promise and also great peril. This is an important book and deserves to be widely read.

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The African Trilogy: Things Fall Apart/No Longer at Ease/Arrow of God (Everyman's Library Classics & Contemporary Classics) (Hardback) - Co

Here, collected for the first time in Everyman's Library, are the three internationally acclaimed classic novels that comprise what has come to be known as Achebe's African Trilogy: "Things Fall Apart, No Longer at Ease," and "Arrow of God."

  • Sales Rank: #7669635 in Books
  • Published on: 2010
  • Binding: Hardcover
  • 513 pages

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Musical Composition, by Reginald Smith Brindle

Musical composition is a key discipline in music programs in conservatories, colleges, and universities. Many teachers consider it as important in the development of young musicians as listening and performance. It can be argued that through compositions musicians achieve the deepest insight into the composer and his music. Musical Composition takes the student through the elements--melody, harmony, counterpoint, and rhythm--before covering a variety of special subjects such as writing vocal and choral music, accompaniments, and film and TV music. Chapters are devoted to recent techniques including free diatonicism, serialism, and indeterminacy. Over 200 examples illustrate points in the text and there are exercises for each chapter.

  • Sales Rank: #268731 in Books
  • Published on: 1986-11-06
  • Original language: English
  • Number of items: 1
  • Dimensions: 5.31" h x .54" w x 8.44" l, .59 pounds
  • Binding: Paperback
  • 188 pages

Review

"Reginald Smith Brindle...is a composer who is also a brilliant communicator and teacher, and he provides just such a variety of suggestions and assignments....In this comprehensive but skillfully concise book, he addresses the needs of those school and university students 'not born with an intuitive grasp of "how to do it," who have a lot to learn [and] who need to be helped over the first hurdles....The range of examples is impressive: from Dowland to Dallapiccola, Purcell to Posseur--a wisely broad spectrum with a significant leaning towards the 20th century. Above all, Smith Brindle has the happy knack of being able to show, in a few words, precisely why a certain technique serves a composer's artistic purpose."--John Paynter, I usical Times


Most helpful customer reviews

36 of 36 people found the following review helpful.
good book for the beginning composer
By J. Chittum
This book is a nice sketch idea of how to compose in a small ensemble or solo setting. the examples given are of good quality and obviously very thoughtful. I would recommend this book for beginning composers. The short chapters provide enough details to understand most topics. For a more mature developing composer, I would recommend Techniques of a Modern Composer by David Cope as well as 20th Century Harmony by Vincent Persechetti. Also, nothing really helps understanding composition than just studying the masters! if you need a good book to help you get started, however, this book definately fits the bill.

29 of 29 people found the following review helpful.
great read and methodology for novice to advanced composers
By K. Sullivan
I highly recommend this wonderful book. I have used it myself to teach beginning composition lessons, and used it as a reference many times for advanced analysis and composition. It's a real down-to-earth read that can be absorbed quickly while retaining many great composition "rules of thumb". Only a moderate understanding of music theory is needed to grasp concepts within the book. Great exercises in the back of the book.

0 of 0 people found the following review helpful.
Probably the best ...
By bibliophile
textbook for Composition available. It's a very tough subject for which to create a textbook, because music can't be composed by recipe. This one has sensible goals and sensible explanations. Like all of them, of course, it needs to be supplemented with other things and sensible assignments created. But this is the third term I've used it, and I still think it's the best there is.

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Minggu, 17 April 2011

[G501.Ebook] Ebook Download Spinning Flight: Dynamics of Frisbees, Boomerangs, Samaras, and Skipping Stones, by Ralph D. Lorenz

Ebook Download Spinning Flight: Dynamics of Frisbees, Boomerangs, Samaras, and Skipping Stones, by Ralph D. Lorenz

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Spinning Flight: Dynamics of Frisbees, Boomerangs, Samaras, and Skipping Stones, by Ralph D. Lorenz

Spinning Flight: Dynamics of Frisbees, Boomerangs, Samaras, and Skipping Stones, by Ralph D. Lorenz



Spinning Flight: Dynamics of Frisbees, Boomerangs, Samaras, and Skipping Stones, by Ralph D. Lorenz

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Spinning Flight: Dynamics of Frisbees, Boomerangs, Samaras, and Skipping Stones, by Ralph D. Lorenz

More frisbees are sold each year than baseballs, basketballs and footballs combined. Yet these familiar flying objects have subtle and clever aerodynamic and gyrodynamic properties which are only recently being documented by wind tunnel and other studies. In common with other rotating bodies discussed in this readily accessible book, they are typically not treated in textbooks of aeronautics and the literature is scattered in a variety of places. This book develops the theme of disc-wings and spinning aerospace vehicles in parallel. Since many of the examples are recreational, anyone who enjoys these activities will likely find it profitable and enjoyable. In addition to spinning objects of various shapes, several exotic manned aircraft with disc planforms have been proposed and a prototypes built – these include a Nazi ‘secret weapon’ and the De Havilland Avrocar, also discussed in the book. Boomerangs represent another category of spinning aerodynamic body whose behavior can only be understood by coupling aerodynamics with gyrodynamics. The narrative, supported by equations and graphs, explains how the shape and throw of a boomerang relates to its trajectory. The natural world presents still other examples, namely the samaras or ‘seed-wings’ of many tree species, which autorotate during their descent, like a helicopter whose engine has failed. The flight performance of these spinning wings directly affects the dispersal and thus the evolutionary competitiveness of the trees concerned. Samara-type configurations are also considered for instrumentation and other payload dispersal applications. In short, the book discusses a range of familiar, connected, but largely undeveloped, topics in an accessible, but complete, manner.

From the reviews of the first edition:

"In his fascinating book Spinning Flight, Ralph Lorenz provides a rich feast of … examples of spinning bodies … . The book is well organized … . The discussion in the book … should be accessible to readers with some elementary understanding of aerodynamic principles. For the expert, the book is full of open problems … . Its scope is extensive … . In this respect, there may be something for everyone within its attractively designed cover … ." (H. K. Moffatt, Nature, Vol. 444, December, 2006)

"If you liked physics at school, then this book is for you. It concerns itself with flying objects that spin through the air, and even tells you how to impress your friends with the biomechanics of Frisbees. … there is plenty of information at all levels, and the book has a wealth of detail that only an aerospace engineer like Lorenz could have come up with." (Len Fisher, BBC Focus, February, 2007)

  • Sales Rank: #1050962 in Books
  • Brand: Springer
  • Published on: 2006-08-30
  • Original language: English
  • Number of items: 1
  • Dimensions: .88" h x 6.36" w x 9.38" l, 1.44 pounds
  • Binding: Hardcover
  • 346 pages
Features
  • Great product!

Review

From the reviews:

"In his fascinating book Spinning Flight, Ralph Lorenz provides a rich feast of … examples of spinning bodies … . The book is well organized … . The discussion in the book … should be accessible to readers with some elementary understanding of aerodynamic principles. For the expert, the book is full of open problems … . Its scope is extensive … . In this respect, there may be something for everyone within its attractively designed cover … ." (H. K. Moffatt, Nature, Vol. 444, December, 2006)

"If you liked physics at school, then this book is for you. It concerns itself with flying objects that spin through the air, and even tells you how to impress your friends with the biomechanics of Frisbees. … there is plenty of information at all levels, and the book has a wealth of detail that only an aerospace engineer like Lorenz could have come up with." (Len Fisher, BBC Focus, February, 2007)

"To my knowledge, Lorenz’s work is the first in which the dynamics of spinning bodies have been treated under a single cover. … Lorenz’s book is written for the general reader who has a basic science education and is eager to learn about physics, even the most esoteric of subjects. … When you want sometime off from the intense working environment of the modern technical world, sit down and read Spinning Flight – and enjoy the ride." (John D. Anderson Jr, Physics Today, December 2007)

From the Back Cover

More frisbees are sold each year than baseballs, basketballs, and footballs combined. Yet these familiar flying objects have subtle and clever aerodynamic and gyrodynamic properties which are only recently being documented by wind tunnel and other studies. In common with other rotating bodies discussed in this readily accessible book, they are typically not treated in textbooks of aeronautics and the literature is scattered in a variety of places.

This book develops the theme of disc-wings and spinning aerospace vehicles in parallel. Many readers will have enjoyed these vehicles and their dynamics in recreational settings, so this book will be of wide interest. In addition to spinning objects of various shapes, several exotic manned aircraft with disc platforms have been proposed and prototypes built - these include a Nazi ‘secret weapon’ and the De Havilland Avrocar, also discussed in the book.

Boomerangs represent another category of spinning aerodynamic body whose behavior can only be understood by coupling aerodynamics with gyrodynamics. The narrative, supported by equations and graphs, explains how the shape and throw of a boomerang relates to its trajectory. The natural world presents still other examples, namely the samaras or ‘seed-wings’ of many tree species, which autorotate during their descent, like a helicopter whose engine has failed.

In short, this book discusses a range of familiar, connected, but largely undeveloped, topics in an accessible, but complete manner. ‘Toys’ familiar to all of us are covered as well as high-tech products of the aerospace industry. Spinning Flight includes not only the latest published results but also describes Lorenz’s own experiments with ‘how-to’ instructions on how readers can do their own experiments.

Most helpful customer reviews

3 of 3 people found the following review helpful.
Be sure what you want to get
By Murat Ozveri
The reason I bought the book was learning more about bioomerangs -more precisely hunting boomerangs- and arrow flight. The very beginning of the book is quite complicated, perhabs due to the professional identity if the author, but is understandable if you have good basics in Physics. All the issues seemed to have been seen and explained from the perspective of an engineer and there is not too much for individuals who look for some practical info. There is almost nothing about straight flying boomerangs (while the returners were well-explained) and literally nothing about arrow flight, which is also acceptable because of the very complex physical character of it. Besides, I found the book well-written by a very knowlegable author. With its hardcover and hi-quality paper and print it would be worth to have it in your library as a reference book about spinning flight. If you know what you would like to get from the book it will be useful.

1 of 1 people found the following review helpful.
From theory to practice to experimentation: A great way to learn!
By David S. Mazel
Spinning Flight by Ralph D. Lorenz is a fine addition to anyone's science library. While the book has a few shortcomings, overall it is a terrific discussion of spinning objects with a good balance of science and examples.

If you read no further, then buy the book and enjoy it. You won't regret it.

The text is a good exposition of the dynamics of flight for a potpourri of objects from balls, bullets, bombs, rockets, satellites, and Frisbees; to spinning parachutes, aircraft, boomerangs, skipping stones and bouncing bombs. Mr. Lorenz provides a short introduction into the mathematics needed to understand and then goes through examples. Lots of examples, applications, and popular activities to see where this work applies.

With each example, he gives you the object, how it behaves, why it behaves as it does, and he even gives graphs that describe these behaviors. The author often tells a story about the objects and how they evolved to objects we use today. The stories bring the science to life--if you don't like the science, you'll still like the stories.

For example, tennis balls. Originally tennis balls were hand stitched so no two flew exactly alike. Now, they are machine made and have a rubber core. The original balls were white, now they are yellow and come in many other colors for better visibility. Because the balls fly at a speed above the critical Reynolds number (see the book for what this is, or do a web search!) the "boundary layer is tripped into turbulence with a spin-dependent location." What does that mean? It means that when you add top spin, the ball will dive downward so a fast shot will still be in-bounds. Current tennis balls have a low drag, making for a fast tennis game. But, Mr. Lorenz tells us, the International Tennis Federation may introduce a larger ball; that would increase the drag and lead to a slower game. This is the basic (but not exhaustive) method of how the text flows. The object is introduced, details of its flight are given, and then some expository text and a story to boot.

Let me cite another example: did you know that if you put spin on a super ball, you can reverse its bounce? If the super ball is spinning backward, then because of its contact friction it can bounce at a backward direction instead of bouncing forward as it would without spin.

One area that's captivating is the spin on bullets, bombs, and rockets. The book gives you a good historical story of the various experiments performed to perfect this idea and it also gives you wonderful pictures of test shots. The book touches on spinning asteroids and how radar can be used to measure the spin period. (I was disappointed that more technical details were not here, but the ideas were still good to know.)

Frisbees are flying objects that most of us know. Naturally, the book discusses them and the treatment is well-done and detailed. It won't make you a better player, but it will make you marvel at how much science is in that platter of plastic.

The boomerang is touched upon, too, and with some historical details. For example, there are a variety of boomerangs depending on one's purpose. Some are used to fly over birds, scaring them to flight and then to capture. Some are heavy, meant for hunting and are intended to strike and thereby stun an animal. The book provides an interesting antidote of a boomerang throw that would be infinite. That is, if there were no ground to intercept the flight, how would the flight path look. It's mostly of theoretical interest but fascinating nonetheless.

I would fault the book for the following, however,. The pictures are okay, but the quality of the photos and graphs is a bit low. Some of the graphs are hard to read. The reader can still understand the plots, but he has to work at it.

The color pictures in the middle of the book would do better had they been placed within the text. That may be something the publisher does for costs but they would have livened-up the material if they appeared with the text.

The author shies away from some mathematics and generally presents his work with few equations. I don't know if that's because there simply aren't equations to describe the behavior (maybe we can only describe the motion through experimentation and plots) but I think there were plenty of opportunities for more in-depth mathematics than the author gave.

To end on a positive note, Mr. Lorenz gives something that others often do not. And it's a bonus worth having. At the end, he gives you a guide, complete with a schematic diagram (parts list, really) and program so that you, the reader, can instrument an object and collect flight data. Thus, the book goes from theory, to practice, to experimentation.

All in all, a great way to learn.

P.S. There's a part about bouncing bombs to avoid torpedo nets. What a cool application of spinning objects!

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